
League of Legends Champion Guide: Twitch, The Plague Rat
A comprehensive guide to Twitch, the Plague Rat - a ranged marksman champion in League of Legends who excels at stealth and poison-based damage.
Twitch uses his deadly venom and stealth abilities to ambush enemies and deal devastating damage over time. His main abilities include:
Passive - Deadly Venom
- Basic attacks apply stacks of poison that deal true damage over time
- Can stack up to 6 times on a single target
Q - Ambush
- Enters camouflage after a brief delay
- Gains movement speed while stealthed
- Grants attack speed when leaving stealth
W - Venom Cask
- Throws a cask that slows enemies and applies poison stacks
- Creates a contaminated zone that applies additional poison
E - Contaminate
- Deals physical damage to all nearby poisoned enemies
- Damage increases with number of poison stacks
R - Spray and Pray
- Grants bonus AD and attack range
- Basic attacks become piercing bolts that can hit multiple targets
- Duration: 6 seconds
Key strengths:
- Excellent at ambushing isolated targets
- Strong sustained damage through poison stacks
- Team fight presence with piercing ultimate
- Good scaling into late game
Best used as an ADC or jungle assassin, Twitch excels at punishing poor positioning and creating chaos in team fights through stealth and widespread poison application.

Twitch, League of Legends plague rat