The ideal Lissandra runes for top lane focus on maximizing her burst damage and utility potential. The most effective combination currently shows a 51.1% win rate across 867 matches in Patch 15.5.

Primary Rune Path: Domination

• Keystone: Electrocute
• Cheap Shot
• Grisly Mementos
• Ultimate Hunter

Secondary Rune Path: Sorcery

• Axiom Arcanist
• Transcendence

Strong Matchups:

• Mel (56.3% WR)
• Akali (54.4% WR)
• Kayle (54.2% WR)
• Aurora (53.7% WR)
• Yasuo (53.4% WR)
• Galio (53.3% WR)

Weak Matchups:

• Taliyah (43.9% WR)
• Swain (44.4% WR)
• Anivia (44.6% WR)
• Annie (45.5% WR)
• Cassiopeia (45.9% WR)
• Cho'Gath (46.7% WR)

Best Jungle Synergies:

• Master Yi (55.7% WR)
• Rammus (55.1% WR)
• Briar (54.8% WR)
• Shyvana (54.8% WR)
• Bel'Veth (53.7% WR)
• Kindred (53.6% WR)

Key Tips:

1. Position Q to hit both minions and enemy champions
2. Use E for flanking maneuvers in team fights
3. When behind, use abilities to peel for your team
4. Ultimate can be used defensively on enemy frontline to protect your carries

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