First Strike serves as the optimal keystone rune for Veigar Mid, boasting a 51.6% win rate in patch 14.23 across 29,574 matches. This setup combines effectively with a strategic rune selection that enhances Veigar's scaling potential and mana management.

Primary Runes (Inspiration):

• First Strike (Keystone)
• Magical Footwear
• Triple Tonic
• Cosmic Insight

Secondary Runes (Sorcery):

• Manaflow Band
• Transcendence

Strong Matchups:

• Smolder (58.8% WR)
• Yone (55.1% WR)
• Sylas (53.4% WR)
• Jayce (53.0% WR)
• Corki (52.6% WR)

Challenging Matchups:

• Akshan (44.7% WR)
• Qiyana (46.1% WR)
• Annie (46.4% WR)
• Zoe (46.8% WR)
• Anivia (46.9% WR)

Best Synergies:

• Jax (55.7% WR)
• Ivern (54.7% WR)
• Skarner (54.6% WR)
• Talon (53.8% WR)
• Briar (53.6% WR)

Key Tips:

1. Conserve your Event Horizon (E) for securing kills or escaping ganks
2. Prioritize Q farming to stack AP
3. Target priority: Use ultimate on vulnerable targets early in teamfights
4. Position multiple minions in line for efficient Q farming and stacking
5. Coordinate cage placement with jungle ganks for maximum effectiveness

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