Lethal Tempo remains the optimal keystone for Top lane Vayne in patch 15.4, boasting a 52.2% win rate across 2,014 matches.

Primary Runes (Precision):

• Lethal Tempo
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Resolve):

• Bone Plating
• Overgrowth

Strong Matchups:

• Mel (60.3% WR)
• Ziggs (54.4% WR)
• Kai'Sa (54.3% WR)
• Ezreal (54.2% WR)
• Sivir (53.6% WR)

Weak Matchups:

• Nilah (46.3% WR)
• Aphelios (49.1% WR)
• Varus (49.5% WR)
• Yasuo (49.6% WR)
• Twitch (49.8% WR)

Best Support Synergies:

• Zyra (57.9% WR)
• Soraka (56.6% WR)
• Milio (55.7% WR)
• Zilean (55.6% WR)
• Seraphine (54.8% WR)

Essential Tips:

1. Maintain maximum range against melee champions
2. Complete three auto-attacks to proc Silver Bolts (W)
3. Save Tumble (Q) for defensive positioning in teamfights
4. Focus on positioning during teamfights
5. Use attack range advantage for safe harassment

Master these aspects to maximize your effectiveness with Vayne in the top lane.

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