Lissandra Support Optimal Runes Guide (Patch 15.5)

Primary Rune Path: Sorcery

• Keystone: Arcane Comet
• Axiom Arcanist
• Absolute Focus
• Gathering Storm

Secondary Rune Path: Domination

• Cheap Shot
• Ultimate Hunter

Current Performance:

• Win Rate: 45.6%
• Pick Rate: 30.5%
• Sample Size: 395 matches

Strong Matchups:

• Mel (56.2% WR)
• Kayle (54.2% WR)
• Akali (54.1% WR)
• Aurora (53.5% WR)
• Galio (53.4% WR)
• Yasuo (53.2% WR)

Challenging Matchups:

• Swain (44.2% WR)
• Taliyah (44.3% WR)
• Anivia (45.3% WR)
• Annie (45.6% WR)
• Cassiopeia (45.8% WR)
• Cho'Gath (46.4% WR)

Best Duo Synergies:

• Master Yi (55.7% WR)
• Rammus (54.8% WR)
• Shyvana (54.7% WR)
• Briar (54.3% WR)
• Darius (53.6% WR)
• Bel'Veth (53.6% WR)

This rune setup maximizes Lissandra's poke potential and ultimate impact in the support role. The combination of Arcane Comet with Cheap Shot provides consistent damage output, while Ultimate Hunter reduces the cooldown of her game-changing ultimate ability.

The secondary runes enhance her ability to control fights and provide utility for her team, making her an effective support pick despite the current below-average win rate.

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