Ziggs optimized rune setup for Bot lane in patch 15.4 achieves a 51.6% win rate with a 57.7% pick rate across 9,196 matches.

Primary Runes (Sorcery):

• Keystone: Arcane Comet
• Manaflow Band
• Transcendence
• Scorch

Secondary Runes (Inspiration):

• Magical Footwear
• Biscuit Delivery

Strong Against:

• Swain (58.9% WR)
• Varus (56.6% WR)
• Aphelios (56.4% WR)
• Mel (55.8% WR)
• Caitlyn (54.2% WR)
• Samira (53.7% WR)

Weak Against:

• Yasuo (39.6% WR)
• Kog'Maw (43.6% WR)
• Hwei (43.7% WR)
• Vayne (44.6% WR)
• Lux (45.5% WR)
• Kai'Sa (46.1% WR)

Best Support Synergies:

• Poppy (56.3% WR)
• Shaco (55.6% WR)
• Lux (55.6% WR)
• Pantheon (55.3% WR)
• Elise (54.9% WR)
• Thresh (54.6% WR)

Key Tips:

1. Avoid extended early-game trades with AD carries
2. Use empowered auto-attacks on champions when safe
3. Poke enemies with Q before teamfights to gain advantage

These runes optimize Ziggs' poke potential and mana sustainability in lane while providing essential utility through the Inspiration tree.

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