Vayne's optimal runes combine Precision and Resolve paths, achieving a 52.2% win rate with 65.3% pick rate across 14,710 matches in patch 15.4.

Primary Runes (Precision)

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Resolve)

• Conditioning
• Overgrowth

Strong Against

• Mel (60.5% WR)
• Ziggs (54.7% WR)
• Kai'Sa (54.4% WR)
• Ezreal (54.3% WR)
• Sivir (53.8% WR)
• Smolder (53.6% WR)

Weak Against

• Nilah (46.4% WR)
• Yasuo (49.2% WR)
• Aphelios (49.2% WR)
• Twitch (49.5% WR)
• Varus (49.7% WR)
• Caitlyn (49.8% WR)

Best Support Synergies

• Zyra (57.8% WR)
• Soraka (56.4% WR)
• Milio (55.6% WR)
• Zilean (55.6% WR)
• Seraphine (54.9% WR)
• Rakan (54.1% WR)

Key Tips

1. Focus on safe farming early game to scale into mid and late game
2. Aim for three consecutive auto-attacks to proc Silver Bolts (W)
3. Position carefully in teamfights and save Tumble (Q) for defensive plays when needed

Essential Combos

• Auto-attack > Tumble (Q) > Condemn (E) for quick trades
• Condemn (E) > Auto-attack > Tumble (Q) for wall stuns
• Final Hour (R) > Tumble (Q) for enhanced stealth plays

This champion excels at late-game scaling and requires precise positioning and mechanical skill to master.

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