First Strike Syndra currently holds a 51.6% win rate in Mid (patch 15.5), with a pick rate of 47.3% across 44,090 matches. The most effective rune combination uses Inspiration primary and Sorcery secondary trees.

Optimal Rune Setup

• Primary (Inspiration): First Strike, Cash Back, Triple Tonic, Jack Of All Trades
• Secondary (Sorcery): Axiom Arcanist, Transcendence

Strong Matchups

• Jayce (56.2% WR)
• Tristana (55.9% WR)
• Mel (55.3% WR)
• Yone (53.9% WR)
• Azir (53.9% WR)
• Hwei (53.2% WR)

Weak Matchups

• Fizz (45.9% WR)
• Katarina (46.7% WR)
• Talon (47.1% WR)
• Zed (47.3% WR)
• Ekko (47.4% WR)
• Aurelion Sol (47.4% WR)

Best Duo Synergies

• Darius (54.9% WR)
• Poppy (54.5% WR)
• Bel'Veth (54.3% WR)
• Qiyana (53.9% WR)
• Nocturne (53.0% WR)
• Wukong (52.9% WR)

Key Tips and Tricks

1. Delay team fights while poking with Q and W, using pre-placed balls for optimal E setup
2. Maximize ball placement before using Ultimate (R) to increase damage output
3. Use Dark Spheres in bushes combined with E for team pick opportunities

The champion has an average difficulty level, requiring practice to master her combos and positioning.

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