Best Yasuo Mid Runes Guide - Patch 15.5 Meta

Best Yasuo Mid Runes Guide - Patch 15.5 Meta

By Marcus Chen

March 19, 2025 at 11:00 AM

Choose your primary keystone as Lethal Tempo, which maintains a 50.4% win rate in mid lane during patch 15.5.

Primary Runes (Precision)

  • Keystone: Lethal Tempo
  • Triumph
  • Legend: Alacrity
  • Cut Down

Secondary Runes (Resolve)

  • Bone Plating
  • Overgrowth

Strong Matchups

  • Mel (55.1% WR)
  • Twisted Fate (54.8% WR)
  • Naafiri (54.7% WR)
  • Akshan (54.6% WR)
  • Katarina (53.7% WR)
  • Fizz (53.2% WR)

Weak Matchups

  • Sett (42.7% WR)
  • Kayle (44.1% WR)
  • Annie (44.2% WR)
  • Taliyah (44.5% WR)
  • Cassiopeia (45.6% WR)
  • Renekton (46.2% WR)

Best Synergies

  • Teemo (54.9% WR)
  • Darius (54.9% WR)
  • Fiddlesticks (54.4% WR)
  • Dr. Mundo (53.3% WR)
  • Nunu & Willump (53.3% WR)
  • Ivern (52.9% WR)

Essential Tips

  1. Use E strategically through minion waves, always leaving one minion as an escape route
  2. Time your ultimate carefully - don't engage on every knock-up
  3. Reserve Windwall for crucial moments, especially during ganks or against global ultimates

Note: Statistics based on 98,628 matches analysis.

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