Patch 15.4 Pyke Mid Runes and Matchups Guide

Pyke Mid currently holds a 45.8% win rate with a 65.1% pick rate across 384 matches.

Optimal Rune Setup Primary (Domination):

• Keystone: Hail of Blades
• Sudden Impact
• Sixth Sense
• Ultimate Hunter

Secondary (Resolve):

• Demolish
• Bone Plating

Weak Against:

• Elise (43.2% WR)
• Taric (43.7% WR)
• Maokai (44.8% WR)
• Thresh (45.3% WR)
• Fiddlesticks (45.7% WR)
• Lulu (46.9% WR)

Strong Against:

• Mel (53.9% WR)
• Senna (53.2% WR)
• Karma (52.2% WR)
• LeBlanc (52.0% WR)
• Leona (51.6% WR)
• Zoe (51.0% WR)

Best Duo Synergies:

• Ziggs (56.2% WR)
• Draven (53.2% WR)
• Jinx (51.3% WR)
• Miss Fortune (51.1% WR)
• Twitch (51.1% WR)
• Vayne (50.9% WR)

Key Strategic Tips:

1. Push waves and roam when Ultimate (R) is available
2. Track enemy Flash cooldowns before using Ultimate
3. In teamfights, flank from the side using Q to catch priority targets

Advanced Gameplay Advice:

• Prioritize wave pushing after completing first item
• Use roaming opportunities to assist side lanes
• Focus on pick potential in teamfights through flanking maneuvers
• Coordinate Ultimate timing with enemy cooldown tracking

Related Articles

Previous Articles