Best Pyke Mid Build Guide - Runes, Items & Strategy (53.8% Win Rate)

Best Pyke Mid Build Guide - Runes, Items & Strategy (53.8% Win Rate)

By Marcus Chen

February 25, 2025 at 08:20 AM

Pyke Mid is a powerful pick with a 53.8% win rate in high-level play. Here's the optimal build and strategy:

Core Build:

  • First Item: Profane Hydra
  • Boots: Ionian Boots of Lucidity
  • Second Item: Youmuu's Ghostblade
  • Late Game: Edge of Night, Opportunity, Death's Dance

Summoner Spells:

  • Flash
  • Teleport

Optimal Runes:

  • Primary: Hail of Blades, Sudden Impact, Grisly Mementos, Ultimate Hunter
  • Secondary: Magical Footwear, Biscuit Delivery
  • Shards: Adaptive Force (x2), Health

Skill Order: Q > E > W

Key Tips:

  • Push wave and roam when Ultimate (R) is available
  • Track enemy Flash cooldowns before engaging with Ultimate
  • Flank from side angles in teamfights using Q
  • Strong early game pressure with roaming potential

Best Matchups:

  • Jayce (83.3% WR)
  • Annie (80% WR)
  • Neeko, Swain, Tryndamere

Avoid Picking Into:

  • Heimerdinger
  • Quinn
  • Vel'Koz
  • Tristana
  • Morgana

Best Synergies:

  • Ziggs (56.4% WR)
  • Draven (53.2% WR)
  • Jinx (51.4% WR)

Alternative Build Path: Start with Hubris into Ionian Boots and Profane Hydra, followed by Opportunity, Serpent's Fang, and Death's Dance (51.8% WR over 56 matches).

Adapt item builds and rune shards based on matchup, particularly choosing between Armor or Magic Resist shards depending on lane opponent.

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