Essential Kai'Sa Runes Guide (Patch 15.3)

The optimal Kai'Sa rune setup combines Precision (primary) with Inspiration (secondary), achieving a 48.3% win rate across 170,236 matches.

Primary Path - Precision:

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Cut Down

Secondary Path - Inspiration:

• Magical Footwear
• Biscuit Delivery

Strong Matchups:

• Mel (51.4% WR)
• Jhin (50.3% WR)
• Ezreal (50.2% WR)

Challenging Matchups:

• Nilah (42.6% WR)
• Kog'Maw (42.9% WR)
• Swain (43.9% WR)

Best Support Synergies:

• Fiddlesticks (53.0% WR)
• Amumu (52.4% WR)
• Braum (50.9% WR)

Key Tips:

1. Prioritize mixed damage items (AD, AP, attack speed) to maximize evolved abilities
2. Use ultimate (R) for strategic repositioning and shield protection in teamfights
3. Target isolated enemies with Q for maximum damage output, avoiding minion interference

Combat Effectiveness:

• Build versatility allows for adaptive playstyles
• Strong dueling potential against isolated targets
• Ultimate provides both offensive and defensive options

Best Duo Lane Partners:

• CC-heavy supports
• Engage-focused champions
• Tank supports with reliable peel

This build focuses on maximizing Kai'Sa's hybrid damage potential while maintaining strong lane presence and teamfight capabilities.

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