Optimal Twitch Runes Guide for Bot Lane

The most effective rune setup for Twitch in patch 15.5 combines Precision (primary) and Sorcery (secondary), achieving a 50.2% win rate across 33,821 matches.

Primary Tree (Precision):

• Keystone: Lethal Tempo
• Presence of Mind
• Legend: Alacrity
• Coup de Grace

Secondary Tree (Sorcery):

• Axiom Arcanist
• Gathering Storm

Strong Against:

• Sivir (55.4% WR)
• Jhin (54.0% WR)
• Aphelios (53.3% WR)
• Varus (52.7% WR)
• Zeri (52.2% WR)

Weak Against:

• Yasuo (40.6% WR)
• Nilah (45.1% WR)
• Seraphine (45.8% WR)
• Corki (47.6% WR)
• Tristana (47.7% WR)

Best Support Synergies:

• Taric (55.1% WR)
• Pantheon (53.8% WR)
• Lulu (53.5% WR)
• Zilean (53.1% WR)
• Leona (52.6% WR)

Key Tips:

1. Position Ultimate (R) to hit maximum targets for optimal damage output
2. Play safely early game until first item completion
3. Prioritize extended trades to maximize passive poison damage

Combat Strategy:

• Focus on extended trades rather than short exchanges
• Utilize poison passive for sustained damage
• Scale into late game through careful early positioning

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