Best Nautilus Mid Runes and Matchups - Patch 15.3 Guide

Best Nautilus Mid Runes and Matchups - Patch 15.3 Guide

By Marcus Chen

February 26, 2025 at 09:08 PM

Nautilus Mid Rune Guide - Patch 15.3

Primary Rune Path: Resolve

  • Keystone: Aftershock
  • Shield Bash
  • Second Wind
  • Overgrowth

Secondary Rune Path: Precision

  • Triumph
  • Legend: Haste

Current Performance:

  • Win Rate: 47.0%
  • Pick Rate: 24.9%
  • Sample Size: 132 matches

Strong Matchups:

  • Yuumi (54.0% WR)
  • Mel (54.0% WR)
  • Pantheon (53.2% WR)
  • Zilean (52.7% WR)
  • Lux (52.5% WR)
  • LeBlanc (52.4% WR)

Weak Matchups:

  • Taric (37.1% WR)
  • Renata Glasc (43.1% WR)
  • Rell (43.3% WR)
  • Tahm Kench (44.5% WR)
  • Bard (45.2% WR)
  • Maokai (45.8% WR)

Best Synergies:

  • Samira (52.3% WR)
  • Swain (52.2% WR)
  • Yasuo (51.7% WR)
  • Miss Fortune (50.9% WR)
  • Nilah (50.9% WR)
  • Sivir (50.9% WR)

This rune setup optimizes Nautilus's engage potential and survivability in the mid lane while providing essential utility through the Precision tree's secondary benefits. The combination of Aftershock's defensive stats and Shield Bash's damage output creates a strong foundation for both trading and all-in scenarios.

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