Lissandra's optimal runes and matchups for Mid Lane, based on 16,073 matches in patch 15.5:

Primary Runes (Domination)

• Keystone: Electrocute (50.6% win rate)
• Taste of Blood
• Grisly Mementos
• Ultimate Hunter

Secondary Runes (Sorcery)

• Axiom Arcanist
• Transcendence

Strong Against (Win Rate)

• Karma (58.4%)
• Mel (56.1%)
• Aurora (54.8%)
• Kayle (54.1%)
• Galio (54.0%)
• Akali (53.9%)

Weak Against (Win Rate)

• Swain (42.8%)
• Anivia (43.8%)
• Taliyah (44.6%)
• Annie (45.2%)
• Vel'Koz (45.6%)
• Cassiopeia (46.6%)

Best Jungle Synergies

• Shyvana (56.5%)
• Master Yi (56.0%)
• Bel'Veth (54.7%)
• Briar (53.8%)
• Hecarim (53.5%)
• Kindred (53.5%)

Key Tips

1. Position Q to hit both minions and enemy champions simultaneously
2. Use E for flanking in team fights, ensuring team can follow up
3. When behind, use abilities to peel for ADC, including Ultimate (R) on enemy frontline

These stats and recommendations are based on current meta analysis and high-elo gameplay patterns.

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