Kai'Sa runes and matchups guide based on 177,688 matches in patch 15.3, featuring a 48.3% win rate with a 75.0% pick rate.

Optimal Rune Setup Primary (Precision):

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Cut Down

Secondary (Inspiration):

• Magical Footwear
• Biscuit Delivery

Strong Against:

• Mel (51.3% WR)
• Jhin (50.3% WR)
• Ezreal (50.2% WR)
• Smolder (49.6% WR)
• Lucian (49.3% WR)
• Ashe (49.1% WR)

Weak Against:

• Nilah (42.6% WR)
• Kog'Maw (43.0% WR)
• Swain (43.7% WR)
• Jinx (45.4% WR)
• Vayne (45.6% WR)
• Aphelios (46.0% WR)

Best Support Synergies:

• Fiddlesticks (53.1% WR)
• Amumu (51.7% WR)
• Zoe (50.8% WR)
• Braum (50.8% WR)
• Alistar (50.3% WR)
• Maokai (50.2% WR)

Essential Tips:

1. Build mixed damage items (AD, AP, and attack speed) to maximize evolved skill potential
2. Use ultimate (R) for repositioning and shield protection in teamfights
3. Target isolated enemies with Q for maximum damage output

Pro Build Resources:

• Current professional builds available on lolvvv
• Additional build statistics and analysis on LoLalytics
• Community discussions available in Kai'Sa mains groups

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