
Kai'Sa Bot Lane Guide: Best Builds, Runes, and Matchups (Patch 15.3)
Kai'Sa Build Guide for Patch 15.3
Best Popular Build (50.5% WR, 97,280 matches):
- Summoner Spells: Flash, Barrier
- Runes: Lethal Tempo, Presence of Mind, Legend: Bloodline, Coup de Grace + Biscuit Delivery, Magical Footwear
- Rune Shards: Attack Speed, Adaptive Force, Health Scaling
- Core Items: Kraken Slayer → Berserker's Greaves → Guinsoo's Rageblade
- Full Build: Add Nashor's Tooth, Zhonya's Hourglass, Rabadon's Deathcap
- Ability Order: Q > E > W
Alternative Build (49.7% WR, 15,006 matches):
- Runes: Press the Attack, Triumph, Legend: Haste, Cut Down + Magical Footwear, Jack Of All Trades
- Core Items: Statikk Shiv → Sorcerer's Shoes → Essence Reaver
- Full Build: Add Shadowflame, Zhonya's Hourglass, Rabadon's Deathcap
- Ability Order: Q > W > E
Key Tips:
- Use mixed damage items (AD, AP, Attack Speed) to evolve multiple abilities
- Position Ultimate (R) strategically in teamfights for survival
- Cast Q when enemies are isolated from minions for maximum damage
Strong Against:
- Mel (51.4% WR)
- Jhin (50.3% WR)
- Ezreal (50.2% WR)
Weak Against:
- Nilah (42.4% WR)
- Kog'Maw (42.9% WR)
- Swain (43.7% WR)
Best Synergies:
- Fiddlesticks (53.3% WR)
- Amumu (52.2% WR)
- Zoe (50.9% WR)
Situational Items:
- Adjust defensive rune shards based on lane opponent (Armor vs AD, Magic Resist vs AP)
- Build path should consider team composition and game state
Related Articles

Ambessa Mid: Complete Champion Guide & Pro Tips for Patch 15.4.1
