Vayne Runes: Precision / Resolve

Primary Runes (Precision)

• Lethal Tempo - 52.4% win rate in patch 15.4
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Resolve)

• Conditioning
• Overgrowth

Best Matchups

• Mel (60.2% WR)
• Ziggs (55.6% WR)
• Smolder (55.3% WR)
• Ezreal (54.4% WR)
• Kai'Sa (54.3% WR)
• Sivir (54.0% WR)

Challenging Matchups

• Nilah (45.7% WR)
• Varus (49.4% WR)
• Caitlyn (49.5% WR)
• Lucian (49.5% WR)
• Twitch (50.0% WR)
• Jinx (50.1% WR)

Best Support Synergies

• Soraka (57.2% WR)
• Milio (56.7% WR)
• Zilean (56.0% WR)
• Leona (55.8% WR)
• Janna (54.7% WR)
• Nami (53.8% WR)

Key Tips

1. Focus on safe farming early game to scale into mid and late game
2. Aim for three consecutive auto-attacks to proc W passive
3. Save Q for defensive repositioning in teamfights
4. Maintain safe positioning in teamfights
5. Prioritize farm and gold acquisition over risky trades early

Note: Current win rate data shows 52.4% with a 65.5% pick rate across 12,785 matches.

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