
Twitch Champion Guide - Complete ADC Assassin Guide for Patch 14.16.1
Starting invisibly with Q – Ambush, Twitch is a unique marksman assassin who excels at surprise attacks and team fight chaos. His passive, Deadly Venom, applies stacks of true damage over time, making him lethal in extended fights.
Core Abilities Overview:
- Passive: Deadly Venom (stackable true damage)
- Q: Ambush (10-14s invisibility + attack speed boost)
- W: Venom Cask (AoE slow + poison)
- E: Contaminate (damage based on poison stacks)
- R: Spray and Pray (increased range + pierce through enemies)
Ability Leveling Priority:
- R (Ultimate at 6/11/16)
- E (Contaminate)
- Q (Ambush)
- W (Venom Cask)
Starting Strategy:
- Begin with Q for level 1 surprise attacks
- Take E at level 2 (standard)
- Consider W start + Doran's Ring against difficult matchups
Core Build Path:
-
Starting Items:
- Standard: Doran's Blade + Health Potion
- Defensive: Doran's Ring (against high-range matchups)
-
Core Items:
- Attack Damage
- Attack Speed
- Critical Strike Chance
- Armor Penetration (late game)
- Lifesteal (sustain)

Man in black shirt headshot
Key Gameplay Tips:
- Use invisibility to position advantageously
- Stack poison on multiple targets before using E
- Save ultimate for team fights or multiple-target scenarios
- Coordinate with support for early lane pressure
- Focus on farming when facing difficult matchups
Twitch excels at creating chaos in team fights through strategic positioning and surprise attacks, making him particularly effective when played with proper timing and positioning.
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