Senna Support Runes: Essential Guide

The optimal rune setup for Support Senna in patch 14.23 maintains a strong 52.1% win rate with a 44.6% pick rate across 7,403 matches.

Primary Tree: Resolve

• Keystone: Grasp of the Undying
• Font of Life
• Second Wind
• Revitalize

Secondary Tree: Precision

• Presence of Mind
• Legend: Alacrity

Strong Against:

• Swain (62.0% WR)
• Brand (60.0% WR)
• Tahm Kench (57.8% WR)
• Ashe (57.5% WR)
• Sylas (57.4% WR)
• Maokai (56.7% WR)

Weak Against:

• Zoe (41.8% WR)
• Shaco (44.1% WR)
• Neeko (46.5% WR)
• Nami (46.9% WR)
• Lux (47.2% WR)
• Blitzcrank (47.5% WR)

Best ADC Synergies:

• Nilah (61.2% WR)
• Xayah (54.8% WR)
• Jhin (53.6% WR)
• Vayne (53.6% WR)
• Draven (53.6% WR)
• Varus (53.5% WR)

Key Tips:

1. Avoid using ultimate (R) mid-combo as it leaves you vulnerable and reduces your DPS
2. Save your E ability for ganks rather than trades to conserve mana
3. Play aggressively at level 1 to establish lane dominance

This setup maximizes Senna's support potential while maintaining strong scaling and utility throughout the game.

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