Precision and Inspiration represent the optimal rune combination for Lee Sin Mid, achieving a 54.5% win rate with a 26.7% pick rate across 112 matches in patch 15.4.

Primary Runes (Precision):

• Keystone: Conqueror
• Triumph
• Legend: Alacrity
• Last Stand

Secondary Runes (Inspiration):

• Magical Footwear
• Cosmic Insight

Strong Matchups:

• Zed (55.0% WR)
• Nidalee (53.9% WR)
• Kha'Zix (53.1% WR)
• Gragas (52.3% WR)
• Rammus (52.1% WR)
• Jarvan IV (52.0% WR)

Weak Matchups:

• Darius (43.5% WR)
• Taliyah (44.7% WR)
• Gwen (45.3% WR)
• Skarner (45.3% WR)
• Rek'Sai (46.5% WR)
• Bel'Veth (46.7% WR)

Best Synergies:

• Annie (54.6% WR)
• Kled (53.7% WR)
• Kassadin (53.6% WR)
• Anivia (53.6% WR)
• Akshan (53.5% WR)
• Swain (53.3% WR)

Essential Tips:

• Don't feel obligated to follow up every Q hit
• Use Flash + Ultimate combo to kick priority targets into your team
• Maintain wave control near your side early game for better trading opportunities

Key Strategies:

1. Landing Q doesn't mandate engagement
2. Flash + R combination can be game-changing
3. Early wave management is crucial for trading

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