Grasp of the Undying remains the optimal keystone rune for K'Sante in patch 14.23, maintaining a 48.5% win rate in the top lane across 88,539 matches.

Primary Runes (Resolve):

• Grasp of the Undying
• Demolish
• Bone Plating
• Overgrowth

Secondary Runes (Inspiration):

• Magical Footwear
• Biscuit Delivery

Strong Matchups:

• Nasus (52.5%)
• Jax (52.2%)
• Gangplank (51.3%)
• Sett (51.1%)
• Smolder (50.9%)
• Irelia (50.8%)

Weak Matchups:

• Singed (42.6%)
• Kayle (42.7%)
• Swain (45.4%)
• Vayne (45.7%)
• Poppy (45.8%)
• Yorick (46.0%)

Best Synergies:

• Gwen (53.4%)
• Pantheon (53.0%)
• Qiyana (52.3%)
• Nunu & Willump (52.0%)
• Jax (51.5%)
• Udyr (51.2%)

Key Tips:

1. Avoid constant pushing during laning phase to maintain ultimate effectiveness
2. Scout for enemy jungler before committing to ultimate engages
3. Use 3rd Q stack threat in early laning phase to gain health advantage

These runes and strategies optimize K'Sante's tank-bruiser playstyle, focusing on lane sustainability and teamfight impact.

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