Kalista optimal runes and matchups guide for Bot lane in patch 15.4:

Primary Runes (Precision)

• Keystone: Lethal Tempo (48.1% win rate)
• Triumph
• Legend: Alacrity
• Cut Down

Secondary Runes (Domination)

• Sudden Impact
• Treasure Hunter

Strong Against:

• Mel (55.8% WR)
• Zeri (52.2% WR)
• Varus (51.7% WR)
• Jhin (50.7% WR)
• Kai'Sa (50.5% WR)
• Ezreal (49.9% WR)

Weak Against:

• Swain (41.5% WR)
• Miss Fortune (41.7% WR)
• Smolder (42.7% WR)
• Aphelios (43.8% WR)
• Corki (44.3% WR)
• Jinx (45.3% WR)

Best Support Synergies:

• Senna (56.0% WR)
• Taric (53.5% WR)
• Thresh (51.6% WR)
• Janna (51.0% WR)
• Swain (51.0% WR)
• Maokai (50.6% WR)

Key Tips:

1. Use Ultimate (R) strategically for engagement or saving your support
2. Hold Rend (E) until skirmish completion to maximize stack damage
3. Scout river vision efficiently with Sentinel (W), maximizing range coverage

These stats are based on analysis of 16,700 matches in the current patch.

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