First Strike is currently the optimal keystone for Syndra mid lane, boasting a 51.6% win rate in Patch 15.6. The most effective rune combination pairs Inspiration primary with Sorcery secondary.

Primary Runes (Inspiration)

• First Strike
• Cash Back
• Triple Tonic
• Jack Of All Trades

Secondary Runes (Sorcery)

• Manaflow Band
• Transcendence

Strong Matchups (Win Rate)

• Tristana (62.5%)
• Mel (62.2%)
• Veigar (60.6%)
• Ryze (58.8%)
• Talon (58.8%)
• Hwei (57.6%)

Weak Matchups (Win Rate)

• Diana (36.6%)
• Kassadin (38.4%)
• Anivia (41.7%)
• Ekko (43.9%)
• LeBlanc (45.4%)
• Katarina (45.9%)

Best Jungle Synergies

• Darius (57.7%)
• Nocturne (57.5%)
• Naafiri (53.5%)
• Hecarim (52.8%)
• Jarvan IV (52.7%)
• Xin Zhao (51.5%)

Key Tips

1. Poke enemies with Q and W before teamfights while positioning Dark Spheres strategically
2. Maximize ultimate damage by having multiple spheres placed before casting
3. Use Dark Spheres in bushes combined with E for surprise stuns and picks

Essential Combos

• Q > E for long-range stun
• Q > W > E for maximum control
• Q > Q > Q > R for burst damage
• E > Q for guaranteed sphere hit

These combinations and strategies are particularly effective when executed with proper positioning and timing.

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