Primary Runes for Elise Support:

Domination (Main Tree)

• Keystone: Electrocute (51.8% win rate)
• Sudden Impact
• Deep Ward
• Relentless Hunter

Precision (Secondary Tree)

• Triumph
• Coup de Grace

Counter Matchups:

Weak Against:

• Taric (43.1% WR)
• Neeko (45.7% WR)
• Sona (46.6% WR)
• Maokai (47.0% WR)
• Braum (48.0% WR)
• Renata Glasc (48.4% WR)

Strong Against:

• LeBlanc (58.7% WR)
• Mel (58.4% WR)
• Sylas (57.3% WR)
• Pyke (56.6% WR)
• Swain (55.1% WR)
• Brand (55.0% WR)

Best ADC Synergies:

• Kog'Maw (57.1% WR)
• Ziggs (56.7% WR)
• Ashe (54.7% WR)
• Draven (53.6% WR)
• Miss Fortune (53.4% WR)
• Sivir (52.4% WR)

These statistics are based on 29,979 matches in patch 15.4, with a total pick rate of 64.8% and an overall win rate of 51.8% for Elise Support.

Note: For detailed combos, build variations, and professional gameplay analysis, consult community resources and professional guides.

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