For optimal performance with Pantheon in mid lane during patch 15.4, focus on the following setup and strategies:

Primary Runes (Precision)

• Keystone: Conqueror
• Presence of Mind
• Legend: Haste
• Last Stand

Secondary Runes (Inspiration)

• Magical Footwear
• Biscuit Delivery

Current Performance: 49.5% win rate with 24.5% pick rate (based on 1,289 matches)

Strong Matchups:

• Sejuani (55.6% WR)
• Karthus (54.1% WR)
• Evelynn (53.6% WR)
• Zyra (51.9% WR)
• Kha'Zix (51.2% WR)
• Talon (51.1% WR)

Weak Matchups:

• Gwen (42.1% WR)
• Rammus (43.9% WR)
• Darius (44.3% WR)
• Rek'Sai (44.8% WR)
• Bel'Veth (44.8% WR)
• Teemo (45.7% WR)

Best Duo Synergies:

• Cho'Gath (56.5% WR)
• Ryze (56.2% WR)
• Swain (55.4% WR)
• Anivia (54.5% WR)
• Volibear (53.4% WR)
• Taliyah (53.3% WR)

Key Strategic Tips:

1. Understand your limited kill pressure in lane, especially post-level 6
2. Against ranged champions, prioritize CS and avoid excessive poke damage
3. Utilize your Ultimate (R) for roaming opportunities after pushing waves
4. Focus on helping other lanes when direct kill pressure isn't available

Remember to adapt your playstyle based on matchups and team composition while maintaining consistent farm and map presence.

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