Kha'Zix is a powerful early-game jungler who excels at isolating and eliminating single targets. With the current patch 15.3, his optimal rune setup achieves a 49.1% win rate with a 33.4% pick rate across 11,028 matches.

Optimal Rune Setup Primary (Domination):

• Keystone: Dark Harvest
• Sudden Impact
• Grisly Mementos
• Treasure Hunter

Secondary (Sorcery):

• Absolute Focus
• Gathering Storm

Strong Against:

• Shyvana (56.3% WR)
• Gwen (55.2% WR)
• Gragas (53.5% WR)
• Sejuani (53.5% WR)
• Evelynn (53.0% WR)

Weak Against:

• Rengar (43.1% WR)
• Ivern (43.2% WR)
• Nunu & Willump (46.3% WR)
• Karthus (46.9% WR)
• Zac (47.3% WR)

Best Duo Synergies:

• Teemo (55.7% WR)
• Gragas (55.6% WR)
• Warwick (54.8% WR)
• Kennen (54.5% WR)
• Xerath (54.1% WR)

Key Tips:

1. Focus on early game skirmishes and ganks to snowball advantages
2. Look for isolated targets to maximize your damage potential
3. Invade enemy jungle when possible to exploit your strong 1v1 potential
4. Prioritize Q evolution at level 6 for maximum effectiveness
5. Use isolation mechanics to your advantage in both ganks and teamfights

Always adapt your playstyle and build according to the specific match composition and situation.

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