Heimerdinger's optimal runes for mid lane in patch 14.23 feature a Sorcery/Inspiration combination, boasting a 53.0% win rate across 2,382 matches.

Primary Runes (Sorcery):

• Arcane Comet (Keystone)
• Manaflow Band
• Absolute Focus
• Gathering Storm

Secondary Runes (Inspiration):

• Magical Footwear
• Biscuit Delivery

Strong Against:

• Illaoi (61.1% WR)
• Tahm Kench (59.2% WR)
• Swain (58.8% WR)
• Rumble (58.7% WR)
• Warwick (58.5% WR)
• Darius (56.8% WR)

Weak Against:

• Cassiopeia (41.6% WR)
• Cho'Gath (42.7% WR)
• Vladimir (45.2% WR)
• Yasuo (45.4% WR)
• Kennen (45.7% WR)
• Dr. Mundo (45.9% WR)

Best Jungle Synergies:

• Udyr (59.0% WR)
• Jarvan IV (54.9% WR)
• Wukong (54.8% WR)
• Bel'Veth (53.2% WR)
• Xin Zhao (52.5% WR)
• Kayn (52.5% WR)

Key Tips:

1. Place turrets before laning phase begins to conserve mana and secure early push
2. Always fight within turret range for maximum damage output
3. Cast stun (E) slightly behind enemies while in turret range for optimal combo effectiveness

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