Cassiopeia Optimal Runes Mid Lane - Patch 14.23

Conqueror build dominates with 52.5% win rate and 72.1% pick rate across 33,105 matches.

Primary: Precision

• Keystone: Conqueror
• Presence of Mind
• Legend: Haste
• Last Stand

Secondary: Sorcery

• Manaflow Band
• Transcendence

Strong Against:

• Smolder (62.5% WR)
• Corki (57.4% WR)
• Swain (56.4% WR)
• Yone (56.0% WR)
• Yasuo (55.7% WR)
• Kassadin (55.7% WR)

Weak Against:

• Vel'Koz (46.5% WR)
• Syndra (46.6% WR)
• Qiyana (46.7% WR)
• Naafiri (46.8% WR)
• Zoe (47.1% WR)
• Anivia (47.3% WR)

Best Jungle Synergies:

• Rammus (58.7% WR)
• Rek'Sai (57.2% WR)
• Ekko (55.4% WR)
• Bel'Veth (55.3% WR)
• Diana (55.2% WR)
• Xin Zhao (54.7% WR)

Key Tips:

1. Monitor mana usage during early trades
2. Only engage after landing Q ability
3. Look for level 2 all-in opportunities against squishier champions
4. Use Q+E combo for optimal damage output

Combos:

• Basic Poke: Q > E
• All-in: Q > R > E spam
• Extended Trade: Q > E spam > W (if enemy tries to escape)

These guidelines are based on current meta analysis and high-elo gameplay patterns.

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