Cassiopeia Mid Lane Runes Guide (Patch 14.23)

Precision + Sorcery runes achieve a 52.6% win rate with a 72.1% pick rate across 32,528 matches.

Primary Tree (Precision):

• Keystone: Conqueror
• Presence of Mind
• Legend: Haste
• Last Stand

Secondary Tree (Sorcery):

• Manaflow Band
• Transcendence

Strong Against:

• Smolder (62.9% WR)
• Corki (57.3% WR)
• Swain (56.6% WR)
• Yone (56.0% WR)
• Yasuo (55.7% WR)
• Kassadin (54.9% WR)

Weak Against:

• Syndra (46.4% WR)
• Qiyana (46.5% WR)
• Vel'Koz (46.7% WR)
• Taliyah (46.9% WR)
• Naafiri (46.9% WR)
• Zoe (47.2% WR)

Best Jungle Synergies:

• Rammus (59.2% WR)
• Rek'Sai (56.8% WR)
• Ekko (55.6% WR)
• Diana (55.4% WR)
• Bel'Veth (55.3% WR)
• Xin Zhao (54.7% WR)

Key Tips:

1. Monitor mana usage carefully during early trades
2. Only engage in extended trades after landing Q
3. Leverage strong level 2 all-in potential against squishier champions
4. Use Q + E spam combo for optimal damage output

For advanced gameplay, combine these runes with proper mana management and skillshot accuracy to maximize Cassiopeia's carry potential in mid lane.

Related Articles

Previous Articles