Anivia's optimal rune setup for Top lane in patch 14.23 focuses on the Domination tree primary with Precision secondary, achieving a 54.7% win rate across 1,622 matches.

Primary Runes (Domination):

• Keystone: Electrocute
• Cheap Shot
• Eyeball Collection
• Relentless Hunter

Secondary Runes (Precision):

• Presence of Mind
• Cut Down

Strong Matchups (>54% Win Rate):

• Smolder (57.7%)
• Vex (57.6%)
• Yone (56.0%)
• Vladimir (55.6%)
• Jayce (55.4%)
• Yasuo (54.9%)

Weak Matchups (<50% Win Rate):

• Naafiri (48.4%)
• Xerath (49.5%)
• Ahri (49.5%)
• Qiyana (49.7%)
• Taliyah (49.9%)
• Aurelion Sol (50.3%)

Best Jungle Synergies:

• Bel'Veth (58.7%)
• Gwen (57.9%)
• Taliyah (56.6%)
• Rammus (56.4%)
• Nocturne (55.9%)
• Ekko (55.0%)

This rune setup maximizes Anivia's burst damage potential while maintaining sufficient mana sustain through Presence of Mind. The combination is particularly effective against immobile champions and team compositions that rely on close-range engagement.

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