Domination and Precision runes provide Anivia with a 52.5% win rate and 59.6% pick rate across 30,928 matches in patch 14.23. Electrocute serves as the optimal keystone choice for mid lane Anivia.

Primary Runes (Domination):

• Electrocute
• Cheap Shot
• Eyeball Collection
• Relentless Hunter

Secondary Runes (Precision):

• Presence of Mind
• Cut Down

Strong Matchups:

• Smolder (57.7% WR)
• Vex (57.6% WR)
• Yone (56.0% WR)
• Vladimir (55.6% WR)
• Jayce (55.4% WR)
• Yasuo (54.9% WR)

Weak Matchups:

• Naafiri (48.4% WR)
• Xerath (49.5% WR)
• Ahri (49.5% WR)
• Qiyana (49.7% WR)
• Taliyah (49.9% WR)
• Aurelion Sol (50.3% WR)

Best Jungle Synergies:

• Bel'Veth (58.7% WR)
• Gwen (57.9% WR)
• Taliyah (56.6% WR)
• Rammus (56.4% WR)
• Nocturne (55.9% WR)
• Ekko (55.0% WR)

Key Tips:

1. Play defensively when passive is on cooldown
2. Use Q to lock down priority targets in teamfights
3. Zone objectives with W and R, but be mindful of W cooldown
4. Focus on peeling for yourself and teammates
5. Utilize wall placement for objective control and picks

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